This application is the national phase under 35 U.S.C. § 371 of PCT International Application No. PCT/EP02/03159 which has an International filing date of Mar. 15, 2002, which designated the United States of America. This application also claims priority of Application No. 01201059.1 filed in Europe on Mar. 20, 2001 under 35 U.S.C. § 119.